LAW, Yuen Kwan,WONG, Kam Wai,WU, An Gao,LIU, Liang,WU, Zeng
申请号：
AU2016101736
公开号：
AU2016101736A4
申请日:
2016.09.29
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
#$%^&*AU2016101736A420161103.pdf#####ABSTRACT The present invention provides a method for treating a subject suffering from a neurodegenerative disease by administering at least one triterpenoid which can be obtained from Hedera helix. Further provided is a method for treating a subject suffering from a 5 neurodegenerative disease by administering an effective amount of a Hedera helix extract which comprises the triterpenoid. The neurodegenerative disease is preferably but not exclusively Parkinsons disease or Huntingtons disease. The present invention also provides methods for extracting the triterpenoid from Hedera helix and a method for inducing autophagy in cells by contacting them with the triterpenoid. o The triterpenoid of the present invention proved to allow an exceptional induction of autophagy, in particular a significant reduction of the protein level of mutant huntingtin, a significant reduction of the protein level of A53T a-synuclein, a significant inhibition of the oligomerization of a-synuclein and a significant inhibition of the inclusion formation of huntingtin via the AMPK-mTOR dependent autophagy inducing pathway. The present 5 invention, thus, provides a highly promising treatment option for treating neurodegenerative diseases. 53
