It is provided a pharmaceutical composition stably containingghrelin or its derivative, which is an endogenous growth hormonesecretagogue (GHS) to a growth hormone secretagogue-receptor (GHS-R),comprising a aqueous solution containing the ghrelins having pH rangeof 2 to 7, wherein the aqueous solution having pH range of 2 to 7 is abuffersolution,especially,glycinehydrochloride buffer, acetatebuffer,citrate buffer, lactate buffer, phosphate buffer, citric acid-phosphatebuffer, phosphate-acetate-borate buffer or phthalate buffer, and theconcentration of the ghrelins in the solution is from 0.03nmol/mL to6µmol/mL.
