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IMPROVEMENT OF LIGHT RESISTANCE OF OXYMETAZOLINE
专利权人:
ШЕРИНГ-ПЛАУ ХЕЛЬСКЕР ПРОДАКТС; ИНК. (US)
发明人:
КИМ Нанхай (US),ЧАНГ Ханвэй Уильям (US)
申请号:
RU2010129833/15
公开号:
RU2010129833A
申请日:
2008.12.19
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. An external decongestant composition comprising:! oxymetazoline or a pharmaceutically acceptable salt thereof; ! at least one of the two substances - polyvinylpyrrolidone or polyethylene glycol; and! buffer solution, where the composition has a pH from about 3 to about 6.! 2. The external decongestant composition according to claim 1, wherein the composition has a pH from about 3.5 to about 5.5. ! 3. The external decongestant composition according to claim 1, where the composition has a pH from about 4 to about 5.! 4. The external decongestant composition according to claim 1, wherein the buffer solution comprises a buffer agent selected from the group consisting of citric acid, sodium citrate, sodium acetate, acetic acid, hydrogen phosphate, dihydrogen phosphate, and combinations thereof. ! 5. The external decongestant composition according to claim 4, wherein the buffering agent is a combination of citric acid and phosphate. ! 6. The external decongestant composition according to claim 5, wherein the buffer solution contains a solution of citric acid and phosphate containing about 0.1 M citric acid and about 0.2 M sodium dihydrogen phosphate monohydrate. ! 7. The external decongestant composition according to claim 1, where oxymetazoline HCl is contained in a concentration of from about 0.01% to about 0.10% weight / vol. composition. ! 8. The external decongestant composition of claim 7, wherein the concentration of oxymetazoline HCl contained is about 0.05% w / v. composition. ! 9. The external decongestant composition according to claim 1, wherein the PVP is contained in a concentration of from about 0.5% to about 15% w / v, and in which the PVP has an average molecular weight of from about 10,000 to about 40,000.! 10. The external decongestant composition of claim 9, wherein the PVP is contained in a concentration of from about 0.5 to about 3% w / v. and has an average molecular weight of about 40,000.! 11. Naru1. Наружная противоотечная композиция, содержащ
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