Method of producing pyrazino[2,1-c][1,2,4]triazine compound

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专利权人:

Ltd.;Prism Pharma Co.

发明人:

Isomura Minetaka,Kosaka Yuki,Nagai Mitsuo,Odagami Takenao,Kouji Hiroyuki

申请号：

AU2014319460

公开号：

AU2014319460A1

申请日:

2014.09.09

申请国别(地区):

AU

年份:

2016

代理人:

摘要：

This method of producing 4-(((6S,9S)-1-(benzylcarbamoyl)-2,9-dimethyl-4,7-dioxo-8-(quinoline-8-ylmethyl) octahydro-1H-pyrazino[2,1-c][1,2,4]triazine-6-yl)methyl) phenyl dihydrogen phosphate involves a step for adding a reaction solution (1) comprising (6S,9S)-N-benzyl-6-(4-hydroxybenzyl)-2,9-dimethyl-4,7-dioxo-8-(quinoline-8-ylmethyl) octahydro-1H-pyrazino[2,1-c][1,2,4]triazine-1-carboxamide, triethylamine and a solvent to a reaction solution (2) comprising a phosphorylating agent and a solvent.

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