(6S, 9S) -N-benzyl-6- (4-hydroxybenzyl) -2,9-dimethyl-4, 7-dioxo-8- (quinolin-8- ylmethyl) octahydro- -Pyrazino [2,1-c] [1,2,4] triazine-1-carboxamide, an organic base and a solvent is added to reaction mixture 2 comprising a phosphorylating agent and a solvent ((6S, 9S) -1- (benzylcarbamoyl) -2,9-dimethyl-4,7-dioxo-8- (quinolin-8- ylmethyl) Pyrazino [2,1-c] [1,2,4] triazin-6-yl) methyl) phenyl dihydrogenphosphate.(6 S, 9 S)-N-벤질-6-(4-히드록시벤질)-2, 9-디메틸-4, 7-디옥소-8-(퀴놀린-8-일메틸)옥타히드로-1 H-피라지노[2, 1-c][1, 2, 4]트리아진-1-카르복사미드, 유기 염기 및 용매를 포함하는 반응 혼합물 1을, 인산화제 및 용매를 포함하는 반응 혼합물 2에 첨가하는 공정을 포함하는, 4-(((6 S, 9 S)-1-(벤질카르바모일)-2, 9-디메틸-4, 7-디옥소-8-(퀴놀린-8-일메틸)옥타히드로-1 H-피라지노[2, 1-c][1, 2, 4]트리아진-6-일)메틸)페닐 디히드로겐 포스페이트의 제조 방법.
