Kim, Jeong-Hoon,Won, Dong-Han,Cha, Bong-Jin,Jang, Sun-Woo,Yoo, Moo-Hi
申请号：
AU2009217927
公开号：
AU2009217927B2
申请日:
2009.02.26
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The present invention relates to a liquid pharmaceutical composition for injection containing docetaxel. The composition of the present invention contains (A) docetaxel and a pharmaceutically acceptable salt, (B) a surface active agent selected from polysorbate, polyoxyethylene glycol ester and polyoxyethylene castor oil derivatives, (C) a solvent containing anhydrous ethanol in the range of concentration of 100 to 800mg/ml in an injection solution, and (D) a pH adjuster of the amount suitable for adjusting pH of the liquid composition to 5 or lower. The composition of the present invention can be directly diluted in a perfusion liquid even without using an intermediary dilute solution in cases where the composition of the present invention is used as injectable preparations as the composition is formed into a single liquid phase. Further, the composition of the present invention is suitable for effective injection of docetaxel as the pharmaceutical stability of the composition is significantly improved.
