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Single liquid stable pharmaceutical composition containing docetaxel
专利权人:
リミテッド;ドン-エー ファーム.カンパニー リミテッド;ファーム.カンパニー;ドン-エー
发明人:
ユ,ム-ヒ,チャ,ボンージン,キム,ジョン―フン,チャン,ソン―ウ,ウォン,ドン―ハン,ユ,ム-ヒ,チャ,ボンージン,キム,ジョン―フン,チャン,ソン―ウ,ウォン,ドン―ハン
申请号:
JP2010548611
公开号:
JP5552438B2
申请日:
2009.02.26
申请国别(地区):
JP
年份:
2014
代理人:
摘要:
This invention relates to a single-liquid pharmaceutical composition for injection containing docetaxel. The composition includes (A) docetaxel and pharmaceutically acceptable salts thereof, (B) a surfactant selected from the group consisting of polysorbate, polyoxyethylene glycol ester and polyoxyethylene castor oil derivatives, (C) a solvent comprising anhydrous ethanol in a concentration range of 100 to 800 mg/ml, in an injectable solution, and (D) a pH adjuster of an amount suitable for adjusting the pH of the liquid composition to 5 or less. The composition may be directly diluted in a perfusion liquid even without the use of an intermediary dilute solution in case the composition is used for injectable preparations since the composition is in a single liquid phase. Furthermore, the composition is suitable for effective administration of docetaxel since the pharmaceutical stability of the composition is significantly improved.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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