The invention relates to water-soluble ketoprofen with a high skin penetration speed and positive charges and a prodrug of a related compound. The invention discloses a compound shown in a structural formula 1, a preparation method of the compound, and application of the compound in preparing a medicine for treating the disease of which the state can be treated through ketoprofen or fenoprofen for people or animals. The invention further discloses a skin penetration treatment application system containing the compound.
