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Oparta na sekwencjach inżynieria i optymalizacja przeciwciał jednołańcuchowych
专利权人:
ESBATech; an Alcon Biomedical Research Unit LLC
发明人:
BORRAS, LEONARDO,URECH, DAVID
申请号:
PL08757277
公开号:
PL2164961T3
申请日:
2008.06.25
申请国别(地区):
PL
年份:
2015
代理人:
摘要:
The invention provides methods of using sequence based analysis and rational strategies to modify and improve the structural and biophysical properties of single chain antibodies (scFvs), including stability, solubility, and antigen binding affinity. These methods and strategies can be used individually or in combination. The methods of the present invention also include the use of a database comprising scFv sequences from an experimentally screened scFv library of antibodies that have been selected to have superior solubility and stability. The invention also provides methods of using the properties found for these selected antibodies in a general approach for reshaping scFv antibodies to improve stability and solubility properties of a single chain antibody fragment.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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