Thorsten Oost;Christian Gnamm;Stefan Peters;Klaus Rudolf
发明人:
Christian Gnamm,Thorsten Oost,Stefan Peters,Klaus Rudolf
申请号：
US14184817
公开号：
US09115093B2
申请日:
2014.02.20
申请国别(地区):
US
年份:
2015
代理人:
摘要：
This invention relates to substituted bicyclic dihydropyrimidinones of formula 1and their use as inhibitors of neutrophil elastase activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of pulmonary, gastrointestinal and genitourinary diseases, inflammatory diseases of the skin and the eye and other autoimmune and allergic disorders, allograft rejection, and oncological diseases.
