ZHU WENYU,GLENN JOSEPH,LI YUN-LONG,YAO WENQING,COMBS ANDREW P.,YUE EDDY W.,MEI SONG,MADUSKUIE THOMAS P. JR.,SPARKS RICHARD B.,DOUTY BRENT,HE CHUNHONG
申请号：
NZ62199112
公开号：
NZ621991A
申请日:
2012.08.31
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
Provided are bicyclic heterocyclylamine derivative compounds, of the general formula I, wherein the variables are as defined in the specification. Examples of the compounds include 1-{ 1-[5-Chloro-3-(1-isopropylazetidin-3-yl)-2-methoxy-4-methylphenyl)ethyl} -3-methyl-1H-pyrazolo[3,4-d)pyrimidin-4-amine bis(trifluoroacetate) and 5-{ 3-[1-(4-Amino-6-methyl-5-oxopyrido[2,3-d)pyrimidin-8(5H)-yl)ethyl)-5-chloro-2-methoxy-6-methylphenyl} -N,N-dimethylpyridine-2-carboxamide bis(trifluoroacetate). The compounds are inhibitors of phosphoinositide 3-kinases (PI3Ks). The compounds are useful in the treatment of cancer, inflammatory diseases and immune diseases.
