PROBLEM TO BE SOLVED: To provide a pharmaceutical composition which stably contains statins and a thiazolidine-system insulin resistance improver.SOLUTION: The pharmaceutical composition contains the following compositions (A) to (C). (A): A compound having an HMG-CoA reductase inhibiting activity expressed by the following general formula (1) [In the formula, R denotes an organic group, and X denotes -CH2-CH2, or -CH=CH-], and one or more kinds selected from the compound and its salt. (B): a thiazolidine-system insulin resistance improver. (C): the pharmaceutical composition containing a basic substance.COPYRIGHT: (C)2012,JPO&INPIT【課題】スタチン類とチアゾリジン系インスリン抵抗性改善剤とを安定に含有する医薬組成物の提供。【解決手段】次の成分(A)~(C):(A)下記一般式(1)[式中、Rは有機基を示し、Xは-CH2-CH2-又は-CH=CH-を示す。]で表されるHMG-CoA還元酵素阻害活性を有する化合物及びその塩から選ばれる1種以上(B)チアゾリジン系インスリン抵抗性改善剤(C)塩基性物質を含有する医薬組成物。【選択図】なし