Birgit SCHOEBERL,Ulrik NIELSEN,Arthur J. KUDLA,Alexey Alexandrovich LUGOVSKOY,Jonathan B. FITZGERALD,Lihui XU,Neeraj KOHLI
申请号：
US15371536
公开号：
US20170210809A1
申请日:
2016.12.07
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Disclosed are bispecific binding agents that specifically target both of the IGF-1 and the ErbB intracellular signaling pathways. For example, bispecific binding agents that comprise an anti-IGF-1R antibody and an anti-ErbB3 antibody connected by a linker are described herein. These bispecific agents are capable of antagonizing signal transduction by both of the IGF-1 and the ErbB signaling pathways and are useful in inhibiting the proliferation of tumor cells whose growth involves the signaling activity of both pathways.
