INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 20 September 2018 (20.09.2018) WIP0 I PCT omit VIII °nolo VIII 100 Kim X10111110 oimIE (10) International Publication Number WO 2018/167379 Al (51) International Patent Classification: A61K 45/06 (2006.01) A61K 9/00 (2006.01) A61K 33/38 (2006.01) A61K 47/59 (2017.01) A61P 31/22 (2006.01) (21) International Application Number: PCT/FI2018/050202 (22) International Filing Date: Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (25) Filing Language: (26) Publication Language: (30) Priority Data: 20175246 19 March 2018 (19.03.2018) English English 17 March 2017 (17.03.2017) FI 1-1 N 1-1 00 1-1 O (72) Inventor； and (71) Applicant: NIEMINEN, Jyri [HAD]； c/o Nolla An- timicrobial SL., Ctra. d'Engolasters Molleres 3 4B, Es- caldes-Engordany, AD700 (AD). (72) Inventor: POYRY, Juha-Pekka； 21 Boulevard Grande- Duchesse Charlotte, 1331 Luxembourg (LU). (74) Agent: SEPPO LAINE OY； Itamerenkatu 3 A, 00180 Helsinki (FI). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ,
