Antiviral compositions, method of manufacturing such compositions and uses of the composition. The present composition is intended for use as an antiviral medicament for topical application on areas of the mammal skin or mucous membranes affected by a herpes virus, in particular herpes simplex virus. The composition comprises silver ions complexed with polyamine polymers, optionally in combination with other antiviral agent. By the present invention, herpes cold sores can be successfully treated or outbreaks thereof even prevented.