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Multi-targeting short interfering RNAs
专利权人:
CITY OF HOPE
发明人:
John J. Rossi,Ola Snove, Jr.,Ali Ehsani,Pal Saetrom, Jr.,Britta Vallazza,Jane Zhang,Lars Aagaard
申请号:
US14579313
公开号:
US09487785B2
申请日:
2014.12.22
申请国别(地区):
US
年份:
2016
代理人:
摘要:
The present invention relates to novel short interfering RNA (siRNA) molecules that are multi-targeted. More specifically, the present invention relates to siRNA molecules that target two or more sequences. In one embodiment, multi-targeting siRNA molecules are designed to incorporate features of siRNA molecules and features of micro-RNA (miRNA) molecules. In another embodiment, multi-targeting siRNA molecules are designed so that each strand is directed to separate targets.
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