A composition consisting of kukoamine A and/or kukoamine B and a method of using thereof are disclosed. The disclosed provides a composition containing at least the kukoamine A or kukoamine B, a use of applying the composition to treat or prevent orthopedics diseases and symptoms, and a method for improving bone health.本申請描述了包括地骨皮甲素和地骨皮乙素中至少一種的組合物及其在治療或預防骨疾病和病症以及增加骨健康方法中的用途。