THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL;VANDERBILT UNIVERSITY
发明人:
DE SILVA, ARAVINDA M.,DE ALWIS, A. RUKLANTHI,WAHALA, WAHALA M.P.B.,BARIC, RALPH S.,MESSER, WILLIAM B.,CROWE, JR., JAMES E.,SMITH, SCOTT A.
申请号：
EP13772201
公开号：
EP2834265A4
申请日:
2013.03.15
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
The present invention provides compositions and methods of use comprising a chimeric dengue virus E glycoprotein comprising a dengue virus E glycoprotein backbone, which comprises amino acid substitutions that introduce a dengue virus E glycoprotein domain I and domain II hinge region from a dengue virus serotype that is different from the dengue virus serotype of the dengue virus E glycoprotein backbone.
