Langer, Robert S.,Anderson, Daniel G.,Goldberg, Michael,Zumbuehl, Andreas,Leshchiner, Elizaveta Sergeyevna
申请号：
AU2006259415
公开号：
AU2006259415B2
申请日:
2006.06.14
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
Nitrogen-containing lipids prepared from the conjugate addition of aminesto acrylates, acrylamides, or other carbon-carbon double bonds conjugatedto electron-withdrawing groups are described. Methods of preparing these lipidsfrom commercially available starting materials are also provided. These amine-containinglipids or salts forms of these lipids are preferably biodegradable and biocompatibleand may be used in a variety of drug delivery systems. Given the amino moiety ofthese lipids, they are particularly suited for the delivery of polynucleotides.Complexes or nanoparticles containing the inventive lipid and polynucleotidehave been prepared. The inventive lipids may also be used to in preparing microparticlefor drug delivery. They are particularly useful in delivering labile agentsgiven their ability to buffer the pH of their surroundings.
