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AMINE-CONTAINING LIPIDS AND USES THEREOF
专利权人:
发明人:
Daniel Griffith Anderson,Andreas Zumbuehl,Elizaveta S. Leshchiner,Robert S. Langer,Michael Solomon Goldberg
申请号:
US14643845
公开号:
US20160009657A1
申请日:
2015.03.10
申请国别(地区):
US
年份:
2016
代理人:
摘要:
Nitrogen-containing lipids prepared from the conjugate addition of amines to acrylates, acrylamides, or other carbon-carbon double bonds conjugated to electron-withdrawing groups are described. Methods of preparing these lipids from commercially available starting materials are also provided. These amine-containing lipids or salts forms of these lipids are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these lipids, they are particularly suited for the delivery of polynucleotides. Complexes or nanoparticles containing the inventive lipid and polynucleotide have been prepared. The inventive lipids may also be used to in preparing microparticle for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
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