An autoinjector comprising a housing in which can be mounted a syringecomprising a barrel for holding a volume of medicament, a needle at one end ofthe barrel in fluid communication with the medicament and a plunger axially-moveable in the barrel to a forwardmost position, the autoinjector furthercomprising a syringe support means for supporting the barrel at an axiallocation at or forward of the forwardmost position of the plunger and having areaction surface for the syringe, whereby in use said reaction surface (109)provides an axial compressive force on said barrel when a forward axial forceis applied to the plunger.