An autoinjector comprising a housing in which can be mounted a syringe comprisinga barrel for holding a volume of medicament, a needle at one end of the barrel influid communication with the medicament and a plunger axially-moveable in thebarrel to a forwardmost position, the autoinjector further comprising a syringesupport means for supporting the barrel at an axial location at or forward of theforwardmost position of the plunger and having a reaction surface for the syringe,whereby in use said reaction surface (109) provides an axial compressive forceon said barrel when a forward axial force is applied to the plunger.