An ophthalmic composition comprising diquafosol or a salt thereof, and a cationic polymer, wherein the cationic polymer is at least one substance selected from the group consisting of chitosan, chitosan derivatives, cationic (meth)acrylate copolymers, cationic silicone polymers, diallyl quaternary ammonium salt/acrylamide copolymers, cationic hydrolyzed keratin, cationic hydrolyzed silk, cationic hydrolyzed collagen, cationic hydrolyzed casein, cationic hydrolyzed soybean protein, cationic vinylpyrrolidone copolymers, polyvinylpyrrolidone, homopolymers of dimethyl diacrylic ammonium chloride, adipic acid/dimethylaminohydroxypropyl diethylenetriamine copolymers, adipic acid/epoxy propyldiethylenetriamine copolymers, and acrylamide/ß-methacroyloxyethyltrimethylammonium methyl sulfate copolymers.
