PHARMACEUTICAL COMPOSITION COMPRISING PISTACIA WEINMANNIFOLIA EXTRACT, FRACTION OF SAME OR COMPOUND SEPARATED FROM SAME FOR PREVENTING OR TREATING CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)
Korea Research Institute of Bioscience and Biotechnology
发明人:
Sei Ryang OH,Kyung Seop AHN,Seung Hyung KIM,In Sik SHIN,Hang JIN,Jung Hee KIM,Hyung Won RYU,Wan Yi LI,Sang Woo LEE,Joong Ku LEE,Sang Ho CHOI
申请号：
US15304316
公开号：
US20170035822A1
申请日:
2015.04.17
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention relates to a composition for suppressing chronic obstructive pulmonary disease (COPD) comprising a Pistacia weinmannifolia extract, a fraction thereof, or a compound isolated therefrom and, more particularly, to a pharmaceutical composition for preventing or treating COPD comprising a Pistacia weinmannifolia extract, a fraction thereof, or a compound isolated therefrom； a food composition for preventing or improving COPD, and the compound isolated therefrom. The composition comprising a Pistacia weinmannifolia extract, a fraction thereof, or a compound isolated therefrom, according to the present invention, is not toxic, suppresses the invasion of inflammatory cells into the bronchial tube of a COPD-induced animal model, and effectively suppresses the expression of CXCL-1, TNF-α, or MIP-2. In addition, due to the use of a safety-proven herbal drug as a raw material, the composition of the present invention can resolve various side-effects of existing therapeutic agents for COPD, chronic obstructive bronchitis, chronic bronchiolitis, emphysema, multiple sclerosis, and acute and chronic inflammation, and thus can be effectively used as a composition for preventing, treating and remedying COPD.
