The present invention relates to a method for in vitro diagnosis of chronic obstructive pulmonary disease (COPD) for determining the expression of the marker gene TMSB 15A. In particular, the invention, DMBT1 optionally a marker gene TMSB15A, KIAA1 T99, DPP6, SLC51B, NUDT11, ELF5, AZGP1, PRRX1, AQP3, SFN, GPR110, GDF15, RASGRF2, RND1, PLA1A, FGG, CEACAM5, HYAL2 determines expression of AHRR, CXCL3, CYP1A1, CYP1B1, CYP1A2, CST6, NTRK2, COMP, ITGA10, CTHRC1, TAL1, FIBIN, BEX5, BEX1, ESM1 and one or more additional marker genes selected from GHRL Relates to an in vitro diagnostic method for assessing the susceptibility of a subject to the development of advanced stage COPD in which the appearance of irreversible lung injury is involved. The present invention relates to a method for preparing TMSB 15A, which comprises contacting TMSB 15A with TMSB 15A and optionally DMBT1, KIAA1 199, DPP6, SLC51B, NUDT11, ELF5, AZGP1, PRRX1, AQP3, SFN, GPR110, GDF15, RASGRF2, RND1, PLA1A, FGG, CEACAM5, HYAL2, AHRR, CXCL3, CYP1A1 , CYP1B1, CYP1A2, CST6, NTRK2, COMP, ITGA10, CTHRC1, TAL1, FIBIN, BEX5, BEX1, ESM1 and determines expression of one or more additional marker genes selected from GHRL, diagnose plateau COPD Or to assess the susceptibility of a subject to the development of stable phase COPD. Furthermore, the invention relates to the use of primers for the transcripts of the marker genes mentioned above in the corresponding in vitro methods, the use of nucleic acid probes for the transcripts of these marker genes, nucleic acid probes for the transcripts of these marker genes And to the use of antibodies against proteins expressed from these marker genes. Determining the expression of a marker gene according to the present invention, also provides in vitro methods of monitoring the progression of COPD.本発明は、マーカー遺伝子TMSB15Aの発現を判定する、慢性閉塞性肺疾患(COPD)のインビトロ診断方法に関する。詳細には、本発明は、マーカー遺伝子TMSB15Aと場合によりDMBT1、KIAA1 T99、DPP6、SLC51B、NUDT11、ELF5、AZGP1、PRRX1、AQP3、SFN、GPR110、GDF15、RASGRF2、RND1、PLA1A、F
