HPYY(1-36) Having a Beta-Homoarginine Substitution at Position 35

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专利权人:

NOVON NORDISK A/S

发明人:

Soeren Oestergaard,Kilian Waldemar Conde Frieboes,Birgit Wieczorek,Jens Kaalby Thomsen,Birgitte Schjellerup Wulff

申请号：

US15036509

公开号：

US20160263197A1

申请日:

2014.11.13

申请国别(地区):

US

年份:

2016

代理人:

摘要：

The invention relates to PYY compounds having the amino acid in the position corresponding to position 35 of hPYY(1-36) substituted with beta-homoarginine and derivatives thereof with a modifying group attached to the position corresponding to position 7 of hPYY(1-36). The compounds of the invention are selective Y2 receptor agonists. The invention also relates to pharmaceutical compositions comprising such PYY compounds and pharmaceutically acceptable excipients, as well as the medical use of the PYY compounds.

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