PLATSCHER, MICHAEL WILHELM,BEHRENDT, RAYMOND,GROEHN, VIOLA,HOERTNER, SIMONE RACHEL,PASSAFARO, MARCO SILVIO,BAUER, FINN
申请号：
CA2867184
公开号：
CA2867184C
申请日:
2013.03.11
申请国别(地区):
CA
年份:
2020
代理人:
摘要：
The present invention is directed to a new class of lipids, more specificallyether-lipidshaving a polar headgroup, as well as vesicles comprising these lipids, methodsoftheir preparation as well as their uses in medical applications, wherein theether-lipidsare represented by general formula (l) wherein Y represents 0, N, S or acovalentbond； Pi represents H, an Y-protecting group or an Y-activating group or aspacergroup； P2, P3 represent independently of each other H, an amino-protectinggroup ora spacer group, or P2 and P3 form together with the N to which they are bounda ringstructure； L is a group of formula (a) wherein the dashed line represents thelinkageto N； Ri represents H or a group of formula ¨(CH2)2-0Rb1； Ri represents H or agroupof formula ¨(CH2)2-ORb2； R2 represents H or a group of formula ¨CH2-ORc, R2represents H or a group of formula ¨ORd or ¨CH2-0FIc； R2 represents H or agroup offormula ¨(CH2)2-0Rd or -(CH2)3-0Re； Rd, Rbi, Rb2, Rc, Rd, Re representindependentlyof each other a saturated or unsaturated, straight or branched hydrocarbonchain,and m is 1, 2 or 3； with the proviso that at least one of Ri, RI, R2, Rz, R3is not H.The lipids of the present invention may be for use in a drug delivery systemor as anantigen display system.
