The present invention provides an anti-thrombogenic modified material, which includes at least one polycarbonate type polyurethane segment, at least one polysiloxane chain segment and at least one anti-thrombogenic end-group, in which the polycarbonate type polyurethane segment has s structural formula of the following formula (I): , wherein R1 and R2 are substituted units, and structural formula of R1 is CyHz, and y is an integer of 1~15, Z is an integer of 2-32. R2 is C2~C8 carbon chain. The polysiloxane chain segment has the structural formula of the following formula (II): , and the anti-thrombogenic end-group is a carboxyl group, an amine group, a guanamine group or isocyanate group. Accordingly, the anti-thrombogenic end-group is bonded with the polycarbonate type polyurethane segment to form an anti-thrombogenic modified material.一種抗凝血藥物之改質材料，具有至少一聚碳酸酯型聚氨酯鏈段、至少一聚矽氧烷鏈段及至少一抗凝血藥物端基，其中聚碳酸酯型聚氨酯鏈段具有如下列式(I)的結構式：，其中R1、R2為取代單元，且R1的結構式為CyHz，y為1-15的整數，z為2-32的整數；R2為C2-C8碳鏈。聚矽氧烷鏈段具有如下列式(II)的結構式：；以及抗凝血藥物端基為羧基、胺基、醯胺基或異氰酸酯基，藉由抗凝血藥物端基與含矽聚碳酸酯型聚氨酯鏈段鍵結以形成抗凝血藥物之改質材料。
