PYRROLO-2,3-B-PYRIDINE COMPOUNDS, AZAIN-DOLES COMPOUNDS USEFUL IN THE SYNTHESIS OF THESE PYRROLO-2,3-B-PYRIDINE COMPOUNDS, METHODS OF MAKING THEM AND USES THEREOF.
Pyrimidin-4-yl-1H-pyrrolo[2,3-b]pyridine compounds (I) and their salts are new. Pyrimidin-4-yl-1H-pyrrolo[2,3-b]pyridine compounds of formula (I) and their salts are new. R 11-10C alkoxy (optionally substituted), halo, 1-10C alkyl, , 1-10C fluoroalkoxy, 1-10C alkoxy-10C alkoxy, 5-8C cycloalkoxy, -OH, -OCOR a, -CN, -NO 2, -SR a, -NR aR b, -NHCOR a, -NHSO 2R a, -NHCONR aR b, NHCO 2R a, phenyl, aryl or heteroaryl； R 2H, R 1 or halo； R 3H, -SO 2R a, -COR a or alkyl； and R 4>；H or NH 2； either R a, R balkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl, cycloalkylalkynyl, heterocycloalkyl, heteocycloalkylalkyl or heterocycloalkylalkenyl (all optionally substituted) or H； or NR aR bheterocycle (optionally substituted by pyrrolidinyl, piperidinyl, piperazinyl or morpholinyl). Independent claims are included for: (1) the preparation of (I)； and (2) a 1H-pyrrolo[2,3-b]pyridine compound of formula (II). [Image] [Image] ACTIVITY : Cytostatic； Neuroprotective； Nootropic； Nephrotropic； Antidiabetic； Antiinflammatory. MECHANISM OF ACTION : Protein kinase inhibitor.
