Robin Löving,Jens Frauenfeld,Gunilla Karlsson Hedestam,Henrik Garoff,Mathilda Sjöberg
申请号：
US15021346
公开号：
US20160220664A1
申请日:
2014.09.12
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The invention refers to a method for producing an antigen comprising at least one hydrophobic or partially hydrophobic antigen molecule from a virus, a bacterium, fungus, protozoan, parasite, a human neoplastic cell or an animal neoplastic, tumour or 5 cancer cell, the method comprising the steps of providing a virus, or cell comprising an antigen molecule, purifying the cell comprising the antigen molecule, solubilizing the antigen molecule in a solubilizing agent that preserves an intact antigen molecule upon solubilisation and reconstituting the antigen molecule in a lipid-binding polypeptide that provides a lipid membrane mimicking environment and a reconstituted antigen particle 10 obtained by this method.
