596868 Disclosed herein are modulators of eosinophilic and neutrophilic function and the use of such modulators for treatment of eosinophil-associated and neutrophil-associated diseases, such as a pulmonary or inflammatory disease. Examples of the modulators disclosed herein are a cyclosporine H derivative of formula I, wherein the variables are defined in the specification, cyclosporine H or dihydro cyclosporine H.
