DE PERETTI, DANIELLE,EVANNO, YANNICK,MACHNIK, DAVID,RAKOTOARISOA, NATHALIE
申请号：
NZ58808309
公开号：
NZ588083A
申请日:
2009.03.20
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed are 2-aryl-6-heteroaryl-imidazo[1,2-a]pyridine derivatives as represented by the general formula (I), wherein: R1 is phenyl, naphthyl, heteroaryl or a heterocyclic ring each of which may be optionally substituted and wherein the remaining substituents are as defined herein. Representative compounds include those such as { 5-[2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]furan-2-yl methanol, [5-(2-quinolin-3-ylimidazo[1,2-a]pyridin-6-yl)furan-2-yl]methanol and the hydrochloride thereof, [4-(2-p-tolylimidazo[1,2-a]pyridin-6-yl)thien-2-yl]methanol, [2-(2-quinolin-3-ylimidazo[1,2-a]pyridin-6-yl)pyridin-4-yl]methanol and the hydrochloride thereof, 4-[6-(5-hydroxymethylfuran-2-yl)imidazo[1,2-a]pyridin-2-yl]-N,N-dimethylbenzamide, N-tert-butyl-5-[6-(5-hydroxymethylthien-3-yl)imidazo[1,2-a]pyridin-2-yl]nicotinamide, { 4-[2-(4-morpholin-4-ylphenyl)imidazo[1,2-a]pyridin-6-yl]thiazol-2-yl} methanol, [4-(2-isoquinolin-5-ylimidazo[1,2-a]pyridin-6-yl)thiazol-2-yl]methanol and N-{ 3-[6-(2-hydroxymethyl-thiazol-4-yl)imidazo[1,2-a]pyridin-2-yl]phenyl} isobutyramide. Further disclosed is a pharmaceutical composition, which comprises a compound of formula (I) as defined above or a pharmaceutically acceptable salt thereof and also at least one pharmaceutically acceptable excipient, for the treatment and prevention of neurodegenerative diseases, cerebral traumas, epilepsy, psychiatric diseases, inflammatory diseases, osteoporosis and / or cancers.
