MASSACHUSETTS INSTITUTE OF TECHNOLOGY;THE CHILDREN'S MEDICAL CENTER CORPORATION
发明人:
LANGER, ROBERT S.,ANDERSON, DANIEL G.,GU, ZHEN,AIMETTI, ALEX ARTHUR
申请号：
CA2902256
公开号：
CA2902256A1
申请日:
2013.02.19
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
A glucose binding amphiphilic peptide hydrogel insulin delivery system that is responsive to glucose concentrations under physiological conditions is provided. Insulin is encapsulated in a glucose binding hydrogel, made from self-assembling amphiphilic peptides including a hydrophobic domain including a beta sheet forming region coupled to a charged hydrophilic domain modified to contain a glucose binding segment. The formulations are designed to release insulin as a function of blood glucose level, maintaining the patients' blood glucose level in an optimum range and avoiding both hyper- and hypoglycemia.
