Robert S. Langer,Daniel G. Anderson,Zhen Gu,Alex Arthur Aimetti
申请号：
US14379477
公开号：
US20150025005A1
申请日:
2013.02.19
申请国别(地区):
US
年份:
2015
代理人:
摘要：
A glucose binding amphiphilic peptide hydrogel insulin delivery system that is responsive to glucose concentrations under physiological conditions is provided. Insulin is encapsulated in a glucose binding hydrogel, made from self-assembling amphiphilic peptides including a hydrophobic domain including a beta sheet forming region coupled to a charged hydrophilic domain modified to contain a glucose binding segment. The formulations are designed to release insulin as a function of blood glucose level, maintaining the patients' blood glucose level in an optimum range and avoiding both hyper- and hypoglycemia.
