對抗檢查點分子之多特異性結合構築體及其用途农业专利-农业专业知识服务系统

发明人:: GONG, BING,贡　兵,貢　兵,RENNARD, RACHEL,瑞纳德　瑞秋,瑞納德　瑞秋,OLIPHANT, AMANDA FRANK,欧里凡特　阿曼达　法兰克,歐里凡特　阿曼達　法蘭克,LEUNG, CHEUK LUN,梁　倬纶,梁　倬綸,WOLF, BENJAMIN JACOB,沃夫　班杰明　雅各布,沃夫　班傑明　雅各布,ESKIOCAK, UGUR,伊斯奇欧卡克　乌葛,伊斯奇歐卡克

摘要：: The present disclosure relates to compositions and methods for inhibiting tumor evasion by reducing immune checkpoint suppression. In some embodiments, provided herein are compositions that block the interaction between PD-1 and its ligand (e.g., PD-1 and/or PD-L2) while promoting the interaction of the cells on which PD-1 and its ligand are expressed. Also provided are methods of using such compositions.本發明係關於藉由減少免疫檢查點抑制來抑制腫瘤逃避之組合物及方法。於一些實施例中，本文中提供組合物，該等組合物阻斷PD-1與其配位體(例如，PD-1及/或PD-L2)之間之相互作用，同時促進PD-1及其配位體在其上表現之細胞的相互作用。本發明亦提供使用此等組合物之方法。