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НОВОЕ АНТИТЕЛО ПРОТИВ НЕТРИНА-1
专利权人:
НЕТРИС ФАРМА
发明人:
Делькро, Жан-Ги,Деан, Ян
申请号:
EA201691212
公开号:
EA201691212A1
申请日:
2015.01.09
申请国别(地区):
EA
年份:
2016
代理人:
摘要:
the invention provides a linear or almost linear epitope \u043d\u0435\u0442\u0440\u0438\u043d\u0430 - 1, which probably corresponds to the specific binding of \u043d\u0435\u0442\u0440\u0438\u043d\u0430 - 1 with \u0440\u0435\u0446\u0435 \u043f\u0442\u043e\u0440\u043e\u043c, in particular, of the class UNC5, especially UNC5B and UNC5A or corresponds to the relative to the specific binding of \u043d\u0435\u0442\u0440\u0438\u043d\u0430 - 1 with \u0440\u0435\u0446\u0435\u043f\u0442\u043e\u0440\u043e\u043c,when binding with \u0430\u043d\u0442\u0438\u0442\u0435\u043b\u043e\u043c prevents interaction \u043d\u0435\u0442\u0440\u0438\u043d\u0430 - 1 with \u0440\u0435\u0446\u0435\u043f\u0442\u043e\u0440\u043e\u043c.detection of linear \u044d\u043f\u0438\u0442\u043e\u043f\u0430 allows the applicant to obtain antibodies \u0441\u0432\u044f\u0437\u044b\u0432\u0430\u044e\u0449\u0438\u0435\u0441\u044f with \u043d\u0435\u0442\u0440\u0438\u043d\u043e\u043c - 1 and prevents the interaction \u043d\u0435\u0442\u0440\u0438\u043d\u0430 - 1 with \u0440\u0435\u0446\u0435\u043f\u0442\u043e\u0440\u043e\u043c, sa to \u0438\u043d\u0434\u0443\u0446\u0438\u0440\u0443\u044f apoptosis or cell death of tumor cells, expression or \u0433\u0438\u043f\u0435\u0440\u044d\u043a\u0441\u043f\u0440\u0435\u0441\u0441\u0438\u0440\u0443\u044e\u0449\u0438\u0445 ntn1 and at least one of the receptors \u043d\u0435\u0442\u0440\u0438\u043d\u0430 - 1, bl \u0430\u0433\u043e\u0434\u0430\u0440\u044f,this interaction inhibits the binding of \u043d\u0435\u0442\u0440\u0438\u043d\u0430 - 1 with \u0440\u0435\u0446\u0435\u043f\u0442\u043e\u0440\u043e\u043c and \u043c\u0443\u043b\u044c\u0442\u0438\u043c\u0435\u0440\u0438\u0437\u0430\u0446\u0438\u044e \u0440\u0435\u0446\u0435\u043f\u0442\u043e\u0440\u0430. the invention is also provided \u043c\u043e\u043d\u043e\u043a\u043b\u043e\u043d\u0430\u043b\u044c\u043d\u043e\u0435 mouse antibody directed against the \u044d\u043f\u0438\u0442\u043e\u043f\u0430 and different \u0433\u0443\u043c\
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