A safe auto-needle device for injection, comprising: • a main housing • a syringe-support for receiving a disposable prefilled syringe said syringe comprises: a piston a proximal end and a distal end terminating in a needle covered by a needle sheath (NS) • a drive mechanism for advancing said syringe-support distally towards an injection site • a tubular needle shield moveable from: a needle covering position, to partially exposed, to needle irreversibly concealed • said generally tubular needle shield comprising a distal end for contacting an injection site, and a proximal end • a spring urging distal movement of said needle shield and said needle shield comprising a spring seat • an NS remover, designed to mate with and irreversibly grip said NS, for removal of said NS prior to injection • a locking mechanism preventing premature advancement of said needle • a plunger rod for engaging said piston, wherein depressing of said plunger is manually controllable wherein in use of said device, said NS remover is removed said distal end of said needle shield is pressed upon an injection site, releasing said locking mechanism, and driving said syringe-support and said syringe, distally until needle penetration and upon depressing of said plunger, a medicament may be injected. The invention additionally provides a novel two-component NS remover.La présente invention concerne un dispositif daiguille automatique sans danger pour injection, comprenant : • un boîtier principal • un support de seringue pour recevoir une seringue pré-remplie jetable, ladite seringue comportant : un piston une extrémité proximale et une extrémité distale se terminant dans une aiguille recouverte par une gaine daiguille (NS) • un mécanisme dentraînement pour faire avancer ledit support de seringue de manière distale vers un point de piqûre • une protection daiguille tubulaire, mobile entre une position de recouvrement daiguille, une position partiellement exposée et une position où laiguille
