Thermoplastic neutralized chitosan composition to form a hydrogel, lyophilizate, and method for producing them

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专利权人:

エス．;ラボラトワール メディドム エス. エー.;ラボラトワール;メディドム;エー．

发明人:

ヤニック シュッツ,ヴァージニー カラッティ－ベッソン,オリバー ジョーダン,ロバート グルニー,ヴァージニー カラッティ-ベッソン

申请号：

JP2008546139

公开号：

JP5474353B2

申请日:

2005.12.23

申请国别(地区):

JP

年份:

2014

代理人:

摘要：

The aqueous thermosetting neutralized chitosan composition, forming a phosphate-free transparent hydrogel at a temperature higher than 5° C., comprises 0.1 to 5.0 w/w %, based on the total composition, of a reacetylated chitosan having a molecular weight of not smaller than 100 kDa and a deacetylation degree of 40 to 70%, neutralized with an hydroxylated base, and 1 to 30 w/w %, based on the total composition, of a complexing agent selected from polyoses and polyols derived from polyoses. Said composition is useful for the preparation of an injectable formulation.

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