Pedro M. Valencia,Eric M. Pridgen,Suresh Gadde,Rohit Karnik,Robert S. Langer,Stephen J. Lippard,Omid C. Farokhzad
申请号：
US14434300
公开号：
US09931410B2
申请日:
2013.10.09
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Provided herein are compositions that contain a nanoparticle containing a plurality of polymers, wherein at least a fraction of the polymers comprise a hydrophobic polymer, a topoisomerase inhibitor, and a Pt-containing chemotherapeutic agent, where the polymers self-assemble in an aqueous liquid to form the nanoparticle, and where the Pt-containing chemotherapeutic agent and the topoisomerase inhibitor are present within the hydrophobic core of the nanoparticle in a ratio of between about 24:1 to about 1:24. Also provided are methods of reducing the proliferation of a cancer cell and methods of treating cancer in a subject that include the use of these compositions. Also provided are methods of making these nanoparticles.
