(R) - and (S) -1- (3- (3-N, N-dimethylaminocarbonyl) phenoxy-4-nitrophenyl) -1-ethyl-N, N¿-bis (ethylene) phosphoramidate, compositions and methods for their uses and preparation
DUAN, Jian-Xin,CAO, Yeyu,CAI, Xiaohong,JIAO, Hailong,MA, Jing Yuan,MATTEUCCI, Mark
申请号：
ES16866977
公开号：
ES2781398T3
申请日:
2016.11.15
申请国别(地区):
ES
年份:
2020
代理人:
摘要：
Provided herein are optically active compounds of the formulae (ii)； and (III) and pharmaceutical compositions thereof. Also provided herein are processes of making these compounds and resolving the racemic mixture or the enrichment of same with in one of its enantiomers to provide (R)- and (S)-1-(3-(3-N,N-dimethylaminocarbonyl)phenoxyl-4-nitrophenyl)-1-ethyl-N,N'-bis(ethylene)phosphoramidate, and methods of treating cancer comprising administering such compounds.
