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"COMPOUND, PHARMACEUTICAL COMPOSITION, METHODS FOR TREATING A CANCER, INHIBITING OR MODULATING LIPID KINASE ACTIVITY, PROCESS FOR PRODUCING PHARMACEUTICAL COMPOSITION, USE OF A COMPOUND AND KIT"
专利权人:
GENENTECH INC;F. HOFFMANN - LA ROCHE AG
发明人:
GEORGETTE CASTANEDO,JENNAFER DOTSON,RICHARD GOLDSMITH,JANET GUNZNER,TIM HEFFRON,SIMON MATHIEU,ALAN OLIVERO,STEVEN STABEN,DANIEL P. SUTHERLIN,VICKIE TSUI,SHUMEI WANG,BING-YAN ZHU,TRACY BAYLISS,IRINA CH
申请号:
BRPI0717907
公开号:
BRPI0717907A2
申请日:
2007.12.05
申请国别(地区):
BR
年份:
2013
代理人:
摘要:
Compounds of Formulas Ia-d where X is S or O, mor is a morpholine group, and R<;SUP>;3 <;/SUP>;is a monocyclic heteroaryl group, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for modulating the activity of lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula Ia-d for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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