Peter R. Paradiso;William P. Hausdorff;George Rainer Siber
发明人:
William P. Hausdorff,George Rainer Siber,Peter R. Paradiso
申请号：
US12357853
公开号：
US08895024B2
申请日:
2009.01.22
申请国别(地区):
US
年份:
2014
代理人:
摘要：
An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) conjugated to a carrier protein. The immunogenic composition, formulated as a vaccine, increases coverage against pneumococcal disease in infants and young children globally, and provides coverage for serotypes 6A and 19A that is not dependent on the limitations of serogroup cross-protection.
