ZHANG, XUQING,ABAD, MARTA C.,GIBBS, ALAN C.,KUO, GEE-HONG,KUO, LAWRENCE C.,SONG, FENGBIN,SUI, ZHIHUA
申请号：
ES11718824
公开号：
ES2545811T3
申请日:
2011.04.21
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of formula (IA) ** ** Formula wherein A is an integer between 0 and 1 X is selected from a group consisting of -O- and -S- R1 is selected from a group consisting of C1-4alkyl and halogenated C1-4 alkyl b is an integer from 0 to 2 R2 is selected from the group consisting of halogen, hydroxy, cyano, nitro, NRARB, C1-4alkyl, -O- C1-4alkyl alkyl, -S- C1-4 and C1-4 halogenated alkyl where RA and RB are each independently selected from a group consisting of hydrogen and C1-4alkyl R3 is selected from a group containing hydrogen, halogen, hydroxy, C1-4 alkyl and -O- NRCRD where RC and RD are each independently selected from a group consisting of hydrogen and C1-4alkyl Y is CH and Z is CH alternatingly Y is CH and Z is N alternatingly Y is N and Z is N Q is selected from a group consisting of - (L1) c- (Ring A), - (L1) c- (Ring B) - (C ring) and - (Ring B) -L1 - (ring C) c is an integer between 0 and 1 L1 is selected from a group consisting of -CH2-, -CH (OH) -, -CH2CH2-, - CH2CH2CH2-, -CH> = CH-, -CH> CH-CH2-, -O-, -O -CH2-, -C (O) -, -C (O) -C (O) -, - C (O) -CH2-, -C (O) -N (R4) -, - N (R4) - , -N (R4) -CH2-, -N (R4) -CH2CH2-, -N (R4) - (CO) -, - N (R4) -C (O) -CH2-, -N (R4) - C (O) -CH2-CH2- and -N (R4) - C (O) -N (R5) - wherein R4 and R5 are each independently selected from a group consisting of hydrogen and C1-2 alkyl The (Ring A) is selected from a group consisting of yl piperazin-1-yl 4-methyl-piperazin-1-3-cyano-phenyl, 3-bencimidamida, azetidin-3-yl, 3-methyl-piperazin -1-yl, 4-ethyl-piperazin-1-yl, 4-isopropyl-piperazin-1- yl, piperazin-4-yl, piperidin-1-yl, piperidin-2-yl, piperidin-3-yl, piperidin -4-yl, 4-amino-piperidin-4-, 4- methyl-piperidin-4-yl, 4-fluoro-piperidin yl-4-yl-piperidin 4-phenyl-4-yl-pyrrolidin-2, , yl pyrrolidin-1-yl pyrid-2-yl pyrid-3-yl pyrid-4-pyrrolidin-3-yl, 3-amino-,, 6-methyl-pyrid-3-yl, 1,2,3 , 6-tetrahydropyrid-4-yl, 1- (methyl- amino-carbonyl) -1,2,3,6-tetrahydropyrid-4-yl 1- (amino-ethyl-carbonyl) -1,2,3,6 -tetrahidropiri
