This invention, it includes the medicine which shows anti- cancer/gun action, according to need the RPN2 gene revelation inhibiter, it uses with aterokoragen as the cancer/gun cell multiplication inhibiter which is prescribed according to need. In addition, it is the anti- cancer/gun medicine which includes this kind of cancer/gun cell multiplication inhibiter.本発明は、RPN2遺伝子発現抑制剤を、必要に応じて抗ガン作用を示す薬剤を含み、必要に応じてアテロコラーゲンとともに投与されるガン細胞増殖抑制剤として使用する。また、このようなガン細胞増殖抑制剤を含む抗ガン剤である。