The present invention relates to and use with solubility neuregulin-1 NRG-1 Neu Differentiation Factor NDF glial growth factors GGF hypotype to the hypotype of the neuregulin-1 NRG-1 Neu Differentiation Factor NDF glial growth factors GGF post translational modification of representative as medicine, treatment cognitive relevant nervous system disease, especially schizophrenia, Alzheimers disease and Parkinsons disease.