Nicholas J. Papadopoulos;Thomas H. Aldrich;Gang Chen;James P. Fandl
发明人:
James P. Fandl,Gang Chen,Nicholas J. Papadopoulos,Thomas H. Aldrich
申请号：
US12466606
公开号：
US08298532B2
申请日:
2009.05.15
申请国别(地区):
US
年份:
2012
代理人:
摘要：
A fusion polypeptide comprising (A)x-M-(A′)y, wherein A and A′ are each polypeptides capable of binding a target receptor. The fusion polypeptides of the invention form multimeric proteins which activate the target receptor. A and A′ may be each be an antibody or fragment derived from an antibody specific for a target receptor, such as the same or different scFv fragments, and/or a ligand or ligand fragment or derivative capable of binding the target protein, M is a multimerizing component, and X and Y are independently a number between 1-10.
