PROBLEM TO BE SOLVED: To provide compounds, compositions and methods for modulating the expression of huntingtin in a cell, tissue or animal.SOLUTION: The present invention provides an antisense oligonucleotide 12 to 35 nucleotides in length, comprising at least 12 consecutive nucleotides, of a specific nucleotide sequence. The present invention also provides a pharmaceutical composition comprising the antisense oligonucleotide, and a pharmaceutically acceptable diluent.SELECTED DRAWING: NoneCOPYRIGHT: (C)2016,JPO&INPIT【課題】細胞、組織、または動物における、ハンチンチンの発現を調節する、化合物、組成物及び方法の提供。【解決手段】特定のヌクレオチド配列の、少なくとも12個の連続したヌクレオチドを含む、長さ12から35ヌクレオチドのアンチセンスオリゴヌクレオチド。前記アンチセンスオリゴヌクレオチド、及び薬学的に許容可能な希釈剤を含む、医薬組成物。【選択図】なし
