A compound comprising a modified oligonucleotide complementary to mir-21； modified oligonucleotide； pharmaceutical composition； method for decreasing collagen expression in a cell； and use of a compound ”
Described herein are compositions and methods for the inhibition of miR-21 activity. The compositions have certain nucleoside modification patterns that yield potent inhibitors of miR-21 activity. The compositions may be used to inhibit miR-21, and also to treat diseases associated with abnormal expression of miR-21, such as fibrosis and cancer.
