A formulation comprises a plurality of seamless minicapsules, the minicapsules having a diameter of from 0.5 mm to 5 mm, the minicapsules having a core containing an active entity and an encapsulating body, the active entity being in the form of any one or more of:-• a microemulsion,• a nanoemulsion,• a self-emulsifying delivery system,• a self-microemulsifying delivery system,• a biostable perflurocarbon formulation,• a complex with cyclodextrin (and the like),• liposomes,• hydrogel,• lymphatic targeted delivery system,• liquid bi-layers,• an aqueous system,• wax,• emzaloid, and• natural plant extract.