A wound care dressing and a manufacturing method thereof are provided. The manufacturing method includes adding a zwitterionic polymer and a hydrophilic material into an excipient and a thermoplastic rubber elastomer, and then heating and mixing to form a dressing material. Next, press-coating the dressing material on the surface of the thin film substrate, so as to form the wound care dressing.本發明提供一種傷口護理用敷料及其製造方法,傷口護理用敷料的製造方法包括以下步驟。首先,將仿生雙離子高分子及親水性材料加入賦型劑及熱塑性橡膠彈性體中,加熱攪拌混合以形成敷料材料。之後,將敷料材料塗佈並加壓於薄膜基材的表面,以形成傷口護理用敷料。